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Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial
The Lancet ( IF 88.5 ) Pub Date : 2025-12-07 , DOI: 10.1016/s0140-6736(25)02360-8 Lorenzo Falchi , Marcel Nijland , Huiqiang Huang , Kim M Linton , John F Seymour , Rong Tao , Michal Kwiatek , Abel Costa , Theodoros P Vassilakopoulos , Richard Greil , Ana Jiménez-Ubieto , Shane A Gangatharan , Ohad Benjamini , Catherine Thieblemont , Alessandra Tucci , Anna Elinder-Camburn , Arpad Illes , Jan Novak , Miguel A Pavlovsky , Andrew McDonald , Dok Hyun Yoon , Dai Maruyama , Gauri Sunkersett , Jian P Mei , Nabanita Mukherjee , Feng Zhu , Abualbishr Alshreef , Elena Favaro , Franck Morschhauser , Panagiotis Tsirigotis , Juliana Pereira , Sonia Gonzalez de Villambrosia , Jayr Schmidt Filho , Irit Avivi , Wojciech Jurczak , Olivier Casasnovas , Juan Miguel Bergua Burgues , Jianzhen Shen , Neta Goldschmidt , Maria Bouzani , Zsolt Nagy , Loic Ysebaert , Roch Houot , Benoit Tessoulin , Gandhi Laurent Damaj , Umberto Vitolo , Juan Manuel Sancho , Vinay Vanguru , Su-Peng Yeh , Xiaojing Yan , Ashley Freeman , Jean-Francois Larouche , Szabolcs Modok , Caterina Patti , Joaquin Sanchez Garcia , Ederson Roberto de Mattos , Patricia Walker , Jeong Ok Lee , Suguru Fukuhara , Yuko Mishima , Jie Jin , Zhengzi Qian , Russell Sterrett , Ronit Gurion , Natalia Rotter , David Belada , Katerina Kopeckova , Marek Trneny , Kamal Bouabdallah , Laure LeBras , Agathe Waultier , Stephanie Guidez , Pierre Feugier , Enrico Derenzini , Gloria Margiotta Casaluci , Blanca Sanchez Gonzalez , Javier Lopez Jiménez , Norma Gutierrez Gutierrez , Guillermo Rodriguez , Ana Carolina Caballero Gonzalez , Eva de Jongh , Wim Terpstra , Joost Vermaat , Tsai-Yun Chen , Hung-Lin Liu , Takayuki Ikezoe , Huijing Wu , Wenyu Li , Hongmei Jing , Adam Kittai , Catherine Diefenbach , Brad Hunter , Netanel Horowitz , Petra Pichler , Gabor Mikala , Andras Masszi , Lubos Drgona , Marie-Christine Ngirabacu , Ann Janssens , Romain Guieze , Eric Durot , Corinne Haioun , Johannes Duell , Enrico Schalk , Monica Tani , Ana Carla Oliveira Ramos , Raul Cordoba Mascunano , Carlos Grande Garcia , Adolfo de la Fuente , Michael Roost Clausen , Troels Thomsen , Ingemar Lagerlof , Inger Nijhof , Roderick Johnson , Danielle Leao Cordeiro de , Ricardo Bigni , Hock Choong Lai , Samar Issa , Dong-Yeop Shin , Cheng-Wei Chou , Hideki Goto , Takafumi Nakao , Caixia Li , Xiaolei Wei , Xudong Wei , Wenbin Qian , Shuo Ma , Vijayalakshmi Donthireddy , Catherine Diefenbach , Mark Fesler , Francisco Hernandez-Ilizaliturri , Moshe Levy , Abhijeet Kumar , Habte Yimer , David Berz , Fernando Cabanillas , Maya Koren Michowitz , Muhit Ozcan , Ozan Salim , Guray Saydam , Mehmet Turgut , Ozgur Mehtap , Mehmet Orhan Ayyildiz , Eirini Katodritou , Meletios-Athanasios Dimopoulos , Peter Rajnics , Vanessa Van Hende , Renaud Roufosse , Inge Vrelust , Nadine Morineau , Sylvain Choquet , Emmanuel Bachy , Julie Abraham , Frank Kroschinsky , Carmen Herling , Marco Ladetto , Potito Scalzulli , Andres Ferreri , Simone Ferrero , Stefan Hohaus , Stefan Kallert , Berit Johansson , Rinske Boersma , Eduard Libourel , Clara Klerk , Matthew Wilson , Rebecca Auer , Shankaranarayana Paneesha , Toby Eyre , David Lewis , Robert Ayto , Wendy Osborne , Luciana Andrea Guanchiale , Hun Chuah , Anita Shetty , Chan Cheah , Allanah Kilfoyle , Won Seog Kim , Ho-Jin Shin , Tomoaki Fujisaki , Takahiro Kumode , Kenji Ishitsuka , Junichiro Yuda , Hisayuki Yokoyama , Koji Kato , Toshio Kitawaki , Tadakazu Kondo , Youko Suehiro , Yoshiaki Ogawa , Hideyuki Nakazawa , Akihiro Tomita , Hirotoshi Kamata , Xun Lai , Yuerong Shuang , Guangxun Gao , Lihong Liu , Haiyan Yang , XiNan Cen
The Lancet ( IF 88.5 ) Pub Date : 2025-12-07 , DOI: 10.1016/s0140-6736(25)02360-8 Lorenzo Falchi , Marcel Nijland , Huiqiang Huang , Kim M Linton , John F Seymour , Rong Tao , Michal Kwiatek , Abel Costa , Theodoros P Vassilakopoulos , Richard Greil , Ana Jiménez-Ubieto , Shane A Gangatharan , Ohad Benjamini , Catherine Thieblemont , Alessandra Tucci , Anna Elinder-Camburn , Arpad Illes , Jan Novak , Miguel A Pavlovsky , Andrew McDonald , Dok Hyun Yoon , Dai Maruyama , Gauri Sunkersett , Jian P Mei , Nabanita Mukherjee , Feng Zhu , Abualbishr Alshreef , Elena Favaro , Franck Morschhauser , Panagiotis Tsirigotis , Juliana Pereira , Sonia Gonzalez de Villambrosia , Jayr Schmidt Filho , Irit Avivi , Wojciech Jurczak , Olivier Casasnovas , Juan Miguel Bergua Burgues , Jianzhen Shen , Neta Goldschmidt , Maria Bouzani , Zsolt Nagy , Loic Ysebaert , Roch Houot , Benoit Tessoulin , Gandhi Laurent Damaj , Umberto Vitolo , Juan Manuel Sancho , Vinay Vanguru , Su-Peng Yeh , Xiaojing Yan , Ashley Freeman , Jean-Francois Larouche , Szabolcs Modok , Caterina Patti , Joaquin Sanchez Garcia , Ederson Roberto de Mattos , Patricia Walker , Jeong Ok Lee , Suguru Fukuhara , Yuko Mishima , Jie Jin , Zhengzi Qian , Russell Sterrett , Ronit Gurion , Natalia Rotter , David Belada , Katerina Kopeckova , Marek Trneny , Kamal Bouabdallah , Laure LeBras , Agathe Waultier , Stephanie Guidez , Pierre Feugier , Enrico Derenzini , Gloria Margiotta Casaluci , Blanca Sanchez Gonzalez , Javier Lopez Jiménez , Norma Gutierrez Gutierrez , Guillermo Rodriguez , Ana Carolina Caballero Gonzalez , Eva de Jongh , Wim Terpstra , Joost Vermaat , Tsai-Yun Chen , Hung-Lin Liu , Takayuki Ikezoe , Huijing Wu , Wenyu Li , Hongmei Jing , Adam Kittai , Catherine Diefenbach , Brad Hunter , Netanel Horowitz , Petra Pichler , Gabor Mikala , Andras Masszi , Lubos Drgona , Marie-Christine Ngirabacu , Ann Janssens , Romain Guieze , Eric Durot , Corinne Haioun , Johannes Duell , Enrico Schalk , Monica Tani , Ana Carla Oliveira Ramos , Raul Cordoba Mascunano , Carlos Grande Garcia , Adolfo de la Fuente , Michael Roost Clausen , Troels Thomsen , Ingemar Lagerlof , Inger Nijhof , Roderick Johnson , Danielle Leao Cordeiro de , Ricardo Bigni , Hock Choong Lai , Samar Issa , Dong-Yeop Shin , Cheng-Wei Chou , Hideki Goto , Takafumi Nakao , Caixia Li , Xiaolei Wei , Xudong Wei , Wenbin Qian , Shuo Ma , Vijayalakshmi Donthireddy , Catherine Diefenbach , Mark Fesler , Francisco Hernandez-Ilizaliturri , Moshe Levy , Abhijeet Kumar , Habte Yimer , David Berz , Fernando Cabanillas , Maya Koren Michowitz , Muhit Ozcan , Ozan Salim , Guray Saydam , Mehmet Turgut , Ozgur Mehtap , Mehmet Orhan Ayyildiz , Eirini Katodritou , Meletios-Athanasios Dimopoulos , Peter Rajnics , Vanessa Van Hende , Renaud Roufosse , Inge Vrelust , Nadine Morineau , Sylvain Choquet , Emmanuel Bachy , Julie Abraham , Frank Kroschinsky , Carmen Herling , Marco Ladetto , Potito Scalzulli , Andres Ferreri , Simone Ferrero , Stefan Hohaus , Stefan Kallert , Berit Johansson , Rinske Boersma , Eduard Libourel , Clara Klerk , Matthew Wilson , Rebecca Auer , Shankaranarayana Paneesha , Toby Eyre , David Lewis , Robert Ayto , Wendy Osborne , Luciana Andrea Guanchiale , Hun Chuah , Anita Shetty , Chan Cheah , Allanah Kilfoyle , Won Seog Kim , Ho-Jin Shin , Tomoaki Fujisaki , Takahiro Kumode , Kenji Ishitsuka , Junichiro Yuda , Hisayuki Yokoyama , Koji Kato , Toshio Kitawaki , Tadakazu Kondo , Youko Suehiro , Yoshiaki Ogawa , Hideyuki Nakazawa , Akihiro Tomita , Hirotoshi Kamata , Xun Lai , Yuerong Shuang , Guangxun Gao , Lihong Liu , Haiyan Yang , XiNan Cen
An unmet need persists for chemotherapy-free regimens that induce durable responses for relapsed or refractory follicular lymphoma. Lenalidomide and rituximab (R2 ) is an accepted standard of care in this population. The EPCORE FL-1 trial aimed to evaluate the efficacy and safety of epcoritamab plus R2 versus R2 in participants with relapsed or refractory follicular lymphoma after at least one previous line of chemoimmunotherapy.
中文翻译：
Epcoritamab、lenalidomide 和 rituximab 对抗复发或难治性滤泡性淋巴瘤（EPCORE FL-1）：一项全球性开放标签随机三期临床试验
对于无化疗方案、能够对复发或难治性滤泡性淋巴瘤产生持久反应的需求依然存在未被满足。来那度胺和利妥昔单抗（R2）是该人群中公认的标准治疗。EPCORE FL-1 试验旨在评估 epcoritamb 加 R2 与 R2 在至少接受过一线化疗免疫治疗后复发或难治性滤泡性淋巴瘤患者的疗效和安全性。
更新日期：2025-12-07
中文翻译：
Epcoritamab、lenalidomide 和 rituximab 对抗复发或难治性滤泡性淋巴瘤（EPCORE FL-1）：一项全球性开放标签随机三期临床试验
对于无化疗方案、能够对复发或难治性滤泡性淋巴瘤产生持久反应的需求依然存在未被满足。来那度胺和利妥昔单抗（R2）是该人群中公认的标准治疗。EPCORE FL-1 试验旨在评估 epcoritamb 加 R2 与 R2 在至少接受过一线化疗免疫治疗后复发或难治性滤泡性淋巴瘤患者的疗效和安全性。
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