Humans have long used various substances to enhance sexual pleasure and performance, often at the expense of their overall health. This review investigates the sexual-related effects of recreational drugs, including amphetamines, 3,4-methylenedioxymethamphetamine (MDMA), mephedrone, gamma-hydroxybutyrate (GHB), and ketamine. By examining anecdotal evidence, self-reports, and limited scientific data, this study aims to clarify the current understanding of these drugs' effects on sexual function. Amphetamines, potent central nervous system stimulants, are associated with increased sexual desire and arousal, delayed ejaculation and prolonged sexual sessions, and heightened orgasm intensity. However, their use is also linked to compulsive sexual behavior, erectile dysfunction with chronic use, and a high risk of dependency. MDMA, known for its empathogenic properties, enhances intimacy, physical sensuality, and sexual desire while intensifying orgasm. Nevertheless, it can impair erectile and ejaculatory function, with prolonged use leading to chronic sexual dysfunction. Mephedrone, a synthetic cathinone with stimulant effects similar to amphetamines, increases sexual desire and reduces inhibitions, though specific evidence regarding its sexual-related impacts remains limited. GHB, with its combined stimulant and depressant properties, is often used to enhance sexual experiences. Its effects include increased arousal, intensified orgasm, lowered inhibitions, and greater sexual openness. However, its use carries a substantial risk of dependency. Finally, ketamine, a dissociative anesthetic used recreationally for its euphoric effects, shows minimal associations with sexual function, with limited evidence pointing to reduced inhibitions. Chronic use is linked to urinary and sexual dysfunction. Across all substances, unsafe sexual behaviors and a heightened risk of STI/HIV transmission emerge as major negative consequences, underscoring the broader health risks associated with sexualized drug use. This review highlights the need for greater awareness of both the perceived benefits and risks of sexualized associated with sexualized drug use. It underscores the necessity for rigorous, controlled research to better understand the effects of these substances on sexual function and calls for the development of legitimate treatment options for sexual dysfunction, which are often inadequately addressed through illicit drug use.

中文翻译：

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“化学诱惑”：对娱乐性药物对性功能的复杂影响的叙述性回顾

长期以来，人类一直使用各种物质来增强性快感和性能力，但往往以牺牲整体健康为代价。本综述调查了消遣性药物的性相关影响，包括苯丙胺 3 （4-methylenedioxymethamphetamineMDMA）、甲氧麻黄酮、γ-羟基丁酸 （GHB） 和氯胺酮。通过检查轶事证据、自我报告和有限的科学数据，本研究旨在阐明目前对这些药物对性功能影响的理解。安非他明是有效的中枢神经系统兴奋剂，与和性唤起增加、射精延迟和性行为时间延长以及性高潮强度增加有关。然而，它们的使用也与强迫性行为、长期使用的勃起功能障碍和依赖的高风险有关。摇头丸以其致病特性而闻名，可增强亲密感、身体性感和，同时增强性高潮。然而，它会损害勃起和射精功能，长期使用会导致慢性性功能障碍。甲氧麻黄酮是一种合成卡西酮，具有类似于苯丙胺的兴奋作用，可增加并减少抑制，但有关其性相关影响的具体证据仍然有限。GHB 具有兴奋剂和抑制剂的结合特性，通常用于增强性体验。它的作用包括增加性唤起、强化性高潮、降低抑制力和更大的性开放性。然而，它的使用存在很大的依赖风险。最后，氯胺酮是一种用于娱乐性的解离麻醉剂，因其欣快作用而使用，它与性功能的关联很小，有限的证据表明抑制作用降低。 长期使用与泌尿和性功能障碍有关。在所有物质中，不安全的性行为和性传播/艾滋病毒传播风险增加成为主要的负面后果，凸显了与性吸毒相关的更广泛的健康风险。本综述强调需要提高对与性化药物使用相关的性化的感知益处和风险的认识。它强调有必要进行严格的、受控的研究，以更好地了解这些物质对性功能的影响，并呼吁制定针对性功能障碍的合法治疗方案，而这些选择往往无法通过非法药物使用得到充分解决。