High-throughput screening offers the potential to expedite labor-intensive experiments more efficiently. In this work, we developed a cost-effective, versatile, and high-throughput microfluidic-based chemical robotic system (Open-HTS) which accomplishes reaction discovery, optimization of reaction conditions, and evaluation of substrate scope with a zoom-in convergent strategy. We demonstrated that 9 hits of new reactions were discovered by exploring 3920 reactions at the time scale of 1.2 min per reaction with this chemical robot. Further automatic optimization and evaluation on chemical parameters, scale, and substrate scopes were conducted for the newly discovered nitrile hydration reaction. This platform can be easily accessed and accelerates reaction discovery conducted by a traditional synthetic laboratory.

中文翻译：

---

使用可访问的高通量筛选 （Open-HTS） 化学机器人系统探索新反应

高通量筛选有可能更有效地加快劳动密集型实验。在这项工作中，我们开发了一种经济高效、多功能和高通量的基于微流体的化学机器人系统 （Open-HTS），该系统通过放大收敛策略完成反应发现、反应条件优化和底物范围评估。我们证明，通过使用该化学机器人在每个反应 1.2 分钟的时间尺度上探索 3920 个反应，发现了 9 个新反应。对新发现的丁腈水合反应的化学参数、规模和底物范围进行了进一步的自动优化和评估。该平台易于访问，并加速了传统合成实验室进行的反应发现。