Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant–tissue interfaces^1,2,3,4. Here we demonstrate that an adhesive implant–tissue interface can mitigate fibrous capsule formation in diverse animal models, including rats, mice, humanized mice and pigs, by reducing the level of infiltration of inflammatory cells into the adhesive implant–tissue interface compared to the non-adhesive implant–tissue interface. Histological analysis shows that the adhesive implant–tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung and heart, over 12 weeks in vivo. In vitro protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis and RNA sequencing are additionally carried out to validate the hypothesis. We further demonstrate long-term bidirectional electrical communication enabled by implantable electrodes with an adhesive interface over 12 weeks in a rat model in vivo. These findings may offer a promising strategy for long-term anti-fibrotic implant–tissue interfaces.

由于异物反应以及随后在植入物-组织界面处形成纤维囊 ^1,2,3,4 ，植入的生物材料和装置长期面临功能和功效受损的问题。在这里，我们证明，与非粘性植入物-组织界面相比，粘性植入物-组织界面可以通过减少炎症细胞浸润到粘性植入物-组织界面的水平来减轻不同动物模型（包括大鼠、小鼠、人源化小鼠和猪）中纤维囊的形成。 -粘合植入物-组织界面。组织学分析表明，在体内 12 周内，粘性植入物-组织界面不会在腹壁、结肠、胃、肺和心脏等多种器官上形成可观察到的纤维胶囊。另外还进行了体外蛋白质吸附、多重 Luminex 测定、定量 PCR、免疫荧光分析和 RNA 测序来验证该假设。我们进一步证明了在大鼠体内模型中，具有粘合界面的植入式电极能够实现超过 12 周的长期双向电通信。这些发现可能为长期抗纤维化植入物-组织界面提供有前景的策略。