Herein, we present a decarboxylative nucleophilic fluorination of carboxylic acids with a silver catalyst. This strategy enables the synthesis of a myriad of diverse and valuable fluorinated motifs under mild conditions, demonstrating good functional-group tolerance and utility in late-stage functionalization. In contrast to traditional electrophilic fluorination, this nucleophilic method utilizes a more readily available nucleophilic fluorinating reagent, providing substantial advantages in terms of cost efficiency, broad substrate scope, and functional-group compatibility.

中文翻译：

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脂肪族羧酸的脱羧亲核氟化


在此，我们提出了用银催化剂对羧酸进行脱羧亲核氟化。该策略使得能够在温和条件下合成无数多样且有价值的氟化基序，表现出良好的官能团耐受性和后期官能化的实用性。与传统的亲电氟化相比，这种亲核方法利用更容易获得的亲核氟化试剂，在成本效益、广泛的底物范围和官能团兼容性方面具有显着的优势。