This study employed computational methods to elucidate the influence of structural features on the cyclization pathways of 1,5-diynes through the 5-endo-dig and 6-endo-dig mechanisms. The results revealed that the nature of the central linker played a significant role in dictating the preferred cyclization pathway. Notably, the capacity of this linker to extend delocalization appears to be the key factor governing the reaction pathway preference.

中文翻译：

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1,5-二炔的环化反应：机制和中心连接体的作用


本研究采用计算方法通过 5-endo-dig 和 6-endo-dig 机制阐明结构特征对 1,5-二炔环化途径的影响。结果表明，中心连接体的性质在决定首选环化途径方面发挥着重要作用。值得注意的是，该接头延长离域的能力似乎是控制反应途径偏好的关键因素。