Background Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.

中文翻译：

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使用临床超极化 13C-MRI 和质谱成像探测富马酸水合酶缺陷型肾癌的瘤内代谢区室化

背景富马酸水合酶缺陷性肾细胞癌（FHd-RCC）是一种罕见的侵袭性肾癌亚型，其特征是富马酸积累增加和乳酸产生上调。肾肿瘤表现出显着的瘤内代谢异质性，这可能导致治疗失败。新兴的非侵入性代谢成像技术具有更准确地表型肿瘤代谢及其异质性的临床潜力。