Laser sources have established their potential effect in inducing hair regrowth. No large cohort study has evaluated the effect of ablative fractional 2940-nm erbium yttrium aluminum garnet (Er: YAG) laser in the treatment of androgenetic alopecia (AGA). To investigate the efficacy and safety of the ablative fractional 2940-nm Er: YAG laser in combination with medication therapy for the treatment of AGA. We performed a retrospective study between first July 2021 to 30th December 2021. All included patients received oral finasteride and topical minoxidil, or combined with six sessions of Er: YAG laser at 2-week intervals. Patients were divided into medication or combined therapy groups. The efficacy of the two therapies was evaluated by the investigator’s Global Assessment (IGA) scores and the patient’s Likert satisfaction scale at week 12 and week 24. Changes in total, terminal and villous hair count, total and terminal hair diameter, and AGA grade were also recorded. Adverse events were evaluated at each follow-up. A total of 192 male patients with AGA were included, including 67 receiving combination treatment, and 125 receiving medication treatment. At week 24, the combination treatment afforded superior outcomes in the IGA score, patient’s global assessment, total and terminal hair counts, and diameters (all P<0.05). No severe adverse events were reported in both groups. The combined therapy of ablative fractional Er: YAG laser and medication was superior in treating male AGA than single medication therapy without serious adverse effects.

激光源已证实其在诱导毛发再生方面的潜在作用。尚无大型队列研究评估消融点阵 2940 nm 铒钇铝石榴石 (Er: YAG) 激光治疗雄激素性脱发 (AGA) 的效果。探讨2940 nm Er: YAG 点阵激光烧蚀联合药物治疗 AGA 的疗效和安全性。我们在 2021 年 7 月 1 日至 2021 年 12 月 30 日期间进行了一项回顾性研究。所有患者均接受口服非那雄胺和外用米诺地尔治疗，或结合 6 次 Er:YAG 激光治疗，间隔为两周。患者被分为药物治疗组或联合治疗组。两种疗法的疗效通过研究者在第12周和第24周时的整体评估（IGA）评分以及患者的Likert满意度量表进行评估。总毛数、终毛数和绒毛数、总毛数和终毛直径以及AGA等级的变化也记录了。每次随访时均评估不良事件。共纳入 192 名 AGA 男性患者，其中 67 例接受联合治疗，125 例接受药物治疗。第 24 周时，联合治疗在 IGA 评分、患者总体评估、总毛发数和终毛数以及直径方面提供了优异的结果（所有P <0.05）。两组均未报告严重不良事件。消融点阵Er:YAG激光与药物联合治疗男性AGA优于单一药物治疗，且无严重不良反应。