In this work, we demonstrate the sodium magnetic resonance imaging (MRI) capabilities of a three-dimensional (3D) dual-echo ultrashort echo time (UTE) sequence with a novel rosette petal trajectory (PETALUTE), in comparison to the 3D density-adapted (DA) radial spokes UTE sequence. We scanned five healthy subjects using a 3D dual-echo PETALUTE acquisition and two comparable implementations of 3D DA-radial spokes acquisitions, one matching the number of k-space projections (Radial – Matched Spokes) and the other matching the total number of samples (Radial – Matched Samples) acquired in k-space. The PETALUTE acquisition enabled equivalent sodium quantification in articular cartilage volumes of interest (168.8 ± 29.9 mM) to those derived from the 3D radial acquisitions (171.62 ± 28.7 mM and 149.8 ± 22.2 mM, respectively). We achieved a 41% shorter scan time of 2:06 for 3D PETALUTE, compared to 3:36 for 3D radial acquisitions. We also evaluated the feasibility of further acceleration of the PETALUTE sequence through retrospective compressed sensing with 2× and 4× acceleration of the first echo and showed structural similarity of 0.89 ± 0.03 and 0.87 ± 0.03 when compared to non-retrospectively accelerated reconstruction. Together, these results demonstrate improved scan time with equivalent performance of the PETALUTE sequence compared to the 3D DA-radial sequence for sodium MRI of articular cartilage.

中文翻译：

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用于 3T 人体关节软骨钠含量体内定量的加速 PETALUTE MRI 序列


在这项工作中，我们展示了具有新颖的玫瑰花瓣轨迹（PETALUTE）的三维（3D）双回波超短回波时间（UTE）序列的钠磁共振成像（MRI）能力，与3D密度相比适应（DA）径向辐条 UTE 序列。我们使用 3D 双回波 PETALUTE 采集和 3D DA 径向辐条采集的两种类似实现扫描了五名健康受试者，一种与 k 空间投影的数量（径向 - 匹配辐条）匹配，另一种与样本总数匹配（径向 - 匹配样本）在 k 空间中获取。 PETALUTE 采集能够对感兴趣的关节软骨体积 (168.8 ± 29.9 mM) 进行与 3D 径向采集（分别为 171.62 ± 28.7 mM 和 149.8 ± 22.2 mM）等效的钠定量。与 3D 径向采集的 3:36 相比，3D PETALUTE 的扫描时间缩短了 41%，为 2:06。我们还评估了通过对第一回波进行 2 倍和 4 倍加速的回顾性压缩感知进一步加速 PETALUTE 序列的可行性，并显示与非回顾性加速重建相比，结构相似性为 0.89 ± 0.03 和 0.87 ± 0.03。总之，这些结果表明，与关节软骨钠 MRI 的 3D DA 径向序列相比，PETALUTE 序列的扫描时间得到了改善，且性能相当。