Mammalian Cell Genotoxicity of Potable Reuse and Conventional Drinking Waters,Environmental Science & Technology

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Mammalian Cell Genotoxicity of Potable Reuse and Conventional Drinking Waters
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2024-05-06 , DOI: 10.1021/acs.est.4c01596
Stephanie S. Lau ₁ , Katherine Bokenkamp _{2,

3} , Aleksander Tecza _{2,

3} , Elizabeth D. Wagner _{2,

3} , Michael J. Plewa _{2,

3} , William A. Mitch ₁

Affiliation

Potable reuse water is increasingly part of the water supply portfolio for municipalities facing water shortages, and toxicity assays can be useful for evaluating potable reuse water quality. We examined the Chinese hamster ovary cell acute direct genotoxicity of potable reuse waters contributed by disinfection byproducts (DBPs) and anthropogenic contaminants and used the local conventional drinking waters as benchmarks for evaluating potable reuse water quality. Our results showed that treatment trains based on reverse osmosis (RO) were more effective than RO-free treatment trains for reducing the genotoxicity of influent wastewaters. RO-treated reuse waters were less genotoxic than the local tap water derived from surface water, whereas reuse waters not treated by RO were similarly genotoxic as the local drinking waters when frequent replacement of granular activated carbon limited contaminant breakthrough. The genotoxicity contributed by nonvolatile, uncharacterized DBPs and anthropogenic contaminants accounted for ≥73% of the total genotoxicity. The (semi)volatile DBPs of current research interest contributed 2–27% toward the total genotoxicity, with unregulated DBPs being more important genotoxicity drivers than regulated DBPs. Our results underscore the need to look beyond known, (semi)volatile DBPs and the importance of determining whole water toxicity when assessing the quality of disinfected waters.

更新日期：2024-05-06

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