Deer velvet extracts' anti-inflammatory and immune-modulatory effects have been widely demonstrated. However, the effects of deer velvet extracts on neuroinflammation and sickness behaviour have only been suggested. This study aimed to test the effect of two deer velvet supplements, SAT and SANT, on preventing LPS-induced systemic inflammation, neuroinflammatory changes and sickness behaviour in mice. Mice diet was supplemented (4 mg/kg/day) with either SAT or SANT or given normal chow as a control for four weeks before receiving a single dose of either LPS (1 mg/kg) or saline. Velvet supplements reduced sickness scores at 6 and 12 h, but not mice activity as measured by open field test at 24 h after LPS injection. Velvet supplements did not affect plasma cytokines but prevented the overexpression of brain inflammation genes and reduced microglial reactivity after 24 h of LPS injection. Results indicate that SAT and SANT modulate sickness behaviour during peak LPS effects and brain inflammation after 24 h of injections through different pathways.

中文翻译：

---

膳食补充 SAT 和 SANT（新西兰鹿茸补充剂）可阻止小鼠全身 LPS 诱导的神经炎症和疾病行为


鹿茸提取物的抗炎和免疫调节作用已被广泛证明。然而，鹿茸提取物对神经炎症和疾病行为的影响仅被提出。本研究旨在测试两种鹿茸补充剂 SAT 和 SANT 对预防 LPS 诱导的小鼠全身炎症、神经炎症变化和疾病行为的效果。在小鼠饮食中添加 SAT 或 SANT（4 毫克/公斤/天），或给予正常食物作为对照，持续 4 周，然后再接受单剂量 LPS（1 毫克/公斤）或盐水。注射 LPS 后 24 小时通过旷场测试测量，天鹅绒补充剂可降低 6 小时和 12 小时的疾病评分，但不能降低小鼠的活动。注射 LPS 24 小时后，天鹅绒补充剂不会影响血浆细胞因子，但可以防止大脑炎症基因的过度表达并降低小胶质细胞的反应性。结果表明，SAT 和 SANT 通过不同途径调节 LPS 峰值作用期间的疾病行为和注射 24 小时后的脑部炎症。