Neurodegenerative disorders such as Parkinson's disease, present a global health concern with limited therapeutic options. In this context, dietary interventions have emerged as a potential strategy to counteract the oxidative stress and inflammation underlying these conditions. Rice bran enzymatic extract (RBEE), rich in bioactive compounds, has shown ability in modulating neuroinflammatory responses and improving mitochondrial function. This study investigates the neuroprotective potential of RBEE in a murine model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The results reveal that RBEE supplementation effectively preserves the dopaminergic population and reduces MPTP-induced gliosis in the Substantia Nigra (SN). Moreover, RBEE enhances mitochondrial Complex I activity in mouse brains.

中文翻译：

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米糠酶提取物补充饮食对帕金森病小鼠模型的神经保护作用


帕金森氏病等神经退行性疾病是全球健康问题，但治疗选择有限。在这种背景下，饮食干预已成为对抗这些疾病背后的氧化应激和炎症的潜在策略。米糠酶提取物 (RBEE) 富含生物活性化合物，具有调节神经炎症反应和改善线粒体功能的能力。本研究探讨了 RBEE 在 1-甲基-4-苯基-1,2,3,6-四氢吡啶 (MPTP) 诱导的 PD 小鼠模型中的神经保护潜力。结果表明，补充 RBEE 可以有效保护黑质 (SN) 中的多巴胺能群体并减少 MPTP 诱导的神经胶质增生。此外，RBEE 还能增强小鼠大脑中线粒体复合物 I 的活性。