This study investigated the beneficial effects of sialic acid (SA) and 3′-Sialyllactose (3′-SL) on the intestinal and cardiovascular health of mice fed with a high-fat diet. Male C57BL/6J mice were administered 0.9 % NaCl, SA, or 3′-SL by gavage throughout the experiment. After eight weeks, the ability of glucose regulation increased, the blood lipid decreased, the serum inflammatory factors decreased, and the SA content of low-density lipoprotein increased in the intervention groups. Transcriptome analysis of the small intestine and colon revealed gene expression patterns related to digestion, absorption, immunity, and the circadian rhythm. Metabonomic analysis of colon contents corroborated the findings of colonic transcriptomics.. The gut microbiome was characterised by an increase in beneficial bacteria and a decrease in harmful bacteria, which correlated with the blood lipid concentration. This study highlights the potential effects of SA and 3′-SL on intestinal health and anti-cardiovascular disease.

中文翻译：

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唾液酸和 3′-唾液酸乳糖对高脂饮食小鼠肠道健康和抗心血管疾病的潜在影响


本研究调查了唾液酸 (SA) 和 3'-唾液酸乳糖 (3'-SL) 对高脂饮食小鼠肠道和心血管健康的有益影响。在整个实验过程中，雄性 C57BL/6J 小鼠通过管饲法施用 0.9% NaCl、SA 或 3'-SL。 8周后干预组血糖调节能力增强、血脂下降、血清炎症因子减少、低密度脂蛋白SA含量升高。小肠和结肠的转录组分析揭示了与消化、吸收、免疫和昼夜节律相关的基因表达模式。结肠内容物的代谢组学分析证实了结肠转录组学的发现。肠道微生物组的特点是有益细菌增加和有害细菌减少，这与血脂浓度相关。这项研究强调了 SA 和 3'-SL 对肠道健康和抗心血管疾病的潜在影响。