The first outbreak of influenza A virus (IAV), which has been circulating for many decades, has resulted in serious morbidity and mortality. The IAV epidemic has caused serious damage to human life and the economy. Following an IAV infection, lymphatic cells immediately enter the lungs to clear the virus and eliminate damaged cells to maintain normal physiological mechanisms. In this study, we used alpha-lipoic acid (ALA), which has versatile antioxidant functions, as a target to treat and evaluate host antiviral effects and immune mechanisms. We observed that pre-treatment with ALA improved the survival rate and pathological state in a mouse model. A reduction in the inflammatory cytokine tumor necrosis factor-alpha was observed following experiments. It also increased the release of antiviral cytokines into the lungs by T lymphocytes. ALA pre-treatment effectively prevented acute pneumonia by modulating immune composition and contributing to virus clearance.

中文翻译：

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α-硫辛酸通过增强抗病毒T细胞免疫力并通过抑制ERK1/2信号通路抑制巨噬细胞活化来改善甲型流感病毒引起的急性肺炎


甲型流感病毒（IAV）的首次爆发已经传播了数十年，导致了严重的发病率和死亡率。 IAV疫情给人类生命和经济造成了严重损害。 IAV感染后，淋巴细胞立即进入肺部清除病毒并消除受损细胞，以维持正常的生理机制。在这项研究中，我们使用具有多种抗氧化功能的α-硫辛酸（ALA）作为治疗和评估宿主抗病毒作用和免疫机制的靶标。我们观察到，ALA 预处理提高了小鼠模型的存活率和病理状态。实验后观察到炎症细胞因子肿瘤坏死因子-α 减少。它还增加了 T 淋巴细胞向肺部释放抗病毒细胞因子。 ALA 预处理通过调节免疫成分和促进病毒清除，有效预防急性肺炎。