Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.

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空肠弯曲菌毒力因子：新出现的问题和趋势的最新情况

空肠弯曲菌是胃肠炎的一种非常常见的原因，并且经常通过受污染的食品或水传播给人类。重要的是，空肠弯曲菌感染具有一系列短期和长期后遗症，例如肠易激综合征和吉兰巴利综合征。空肠弯曲菌通过采用一系列分子策略来引发疾病，这些策略使其能够在肠道定殖、侵入上皮、在细胞内持续存在并避免被宿主免疫反应检测到。本综述的目的是探索和总结空肠弯曲菌定植、细胞侵袭、集体群体感应介导的行为和持久性相关分子因素的最新进展。了解空肠弯曲菌致病性的机制将使未来能够开发针对这种病原体的有效预防方法和疫苗。