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Electrochemical Decarboxylative Addition of N-Aryl Glycines to Enaminones: Access to C3-Aminomethyl Chromones
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2024-05-01 , DOI: 10.1002/ejoc.202400401
Siyang Han 1 , Chengcheng Fang 1 , Yaoge Zhang 1 , Sifeng Li 2 , Min Huang 1 , Taimin Wang 1 , Baigang An 3 , Bin Cheng 1
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An electrochemical decarboxylative addition of N-substituted glycines to enaminones has been developed for the synthesis of C3-aminomethyl chromones. The products could be generated under oxidant-, catalyst-, and light-free conditions at room temperature, and could act as valuable building blocks to construct polysubstituted pyrimidines with potential bioactivities.

中文翻译:

N-芳基甘氨酸与烯胺酮的电化学脱羧加成:获得 C3-氨甲基色酮

已开发出一种N-取代甘氨酸与烯胺酮的电化学脱羧加成方法,用于合成 C3-氨甲基色酮。该产物可以在室温下、无氧化剂、无催化剂和无光的条件下生成,并且可以作为有价值的构建模块来构建具有潜在生物活性的多取代嘧啶。
更新日期:2024-05-01
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