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Radiomic analysis of patient and inter-organ heterogeneity in response to immunotherapies and BRAF targeted therapy in metastatic melanoma
medRxiv - Radiology and Imaging Pub Date : 2024-04-27 , DOI: 10.1101/2024.04.26.24306411 Alexandra Tompkins , Zane N. Gray , Rebekah E. Dadey , Serafettin Zenkin , Nasim Batavani , Sarah Newman , Afsaneh Amouzegar , Murat Ak , Nursima Ak , Taha Yasin Pak , Vishal Peddagangireddy , Priyadarshini Mamindla , Sarah Behr , Amy Goodman , Darcy L. Ploucha , John M. Kirkwood , Hassane M. Zarour , Yana G. Najjar , Diwakar Davar , Rivka Colen , Jason J. Luke , Riyue Bao
medRxiv - Radiology and Imaging Pub Date : 2024-04-27 , DOI: 10.1101/2024.04.26.24306411 Alexandra Tompkins , Zane N. Gray , Rebekah E. Dadey , Serafettin Zenkin , Nasim Batavani , Sarah Newman , Afsaneh Amouzegar , Murat Ak , Nursima Ak , Taha Yasin Pak , Vishal Peddagangireddy , Priyadarshini Mamindla , Sarah Behr , Amy Goodman , Darcy L. Ploucha , John M. Kirkwood , Hassane M. Zarour , Yana G. Najjar , Diwakar Davar , Rivka Colen , Jason J. Luke , Riyue Bao
Background Variability in treatment response may be attributable to organ-level heterogeneity in tumor lesions. Radiomic analysis of medical images can elucidate non-invasive biomarkers of clinical outcome. Organ-specific radiomic comparison across immunotherapies and targeted therapies has not been previously reported.
中文翻译:
转移性黑色素瘤免疫治疗和 BRAF 靶向治疗对患者和器官间异质性的放射组学分析
背景治疗反应的变异性可能归因于肿瘤病变的器官水平异质性。医学图像的放射组学分析可以阐明临床结果的非侵入性生物标志物。免疫疗法和靶向疗法之间的器官特异性放射组学比较此前尚未有报道。
更新日期:2024-04-30
中文翻译:
转移性黑色素瘤免疫治疗和 BRAF 靶向治疗对患者和器官间异质性的放射组学分析
背景治疗反应的变异性可能归因于肿瘤病变的器官水平异质性。医学图像的放射组学分析可以阐明临床结果的非侵入性生物标志物。免疫疗法和靶向疗法之间的器官特异性放射组学比较此前尚未有报道。