A general and highly efficient asymmetric hydrogenation of allylic sulfones catalyzed by the Rh-(R,R)-f-spiroPhos complex has been developed affording chiral β-ester sulfones in high yields with excellent enantioselectivities (92–99.9% ee). The gram-scale hydrogenation was also successfully realized and this method can be used as an efficient concise synthetic route to key chiral intermediates of renin inhibitors: CGP 38 560 A and the macrocyclic renin inhibitors.

中文翻译：

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Rh催化烯丙基砜不对称氢化合成手性β-酯砜

由 Rh-( R , R )-f-spiroPhos 络合物催化的烯丙基砜的通用高效不对称氢化已被开发出来，以高产率提供手性 β-酯砜，具有优异的对映选择性 (92–99.9% ee)。克级加氢也成功实现，该方法可作为肾素抑制剂关键手性中间体CGP 38 560 A和大环肾素抑制剂的高效、简洁的合成路线。