INTRODUCTIONThis study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.METHODSMultiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.RESULTSLA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or posterior wall thickness and ventricular mass) were associated with higher CSF phosphorylated (p)‐tau and total (t)‐tau levels, and poorer cognition. Tau pathologies mediated the heart‐cognition relationships. Cardiac parameters were higher in stage 2 and suspected non‐Alzheimer's pathology groups than controls.DISCUSSIONThese findings suggested close associations of subclinical cardiac changes with tau pathologies and cognition.Highlights Various subclinical alterations in the left heart related to poorer cognition. Subclinical cardiac changes related to tau pathologies in cognitively normal adults. Tau pathologies mediated the heart‐cognition relationships. Subclinical cardiac changes related to the AD continuum, especially to stage 2. The accumulation of cardiac alterations magnified their damage to the brain.

中文翻译：

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认知完整成人阿尔茨海默病病理学左心和脑脊液生物标志物的超声心动图测量：CABLE 研究

引言本研究描绘了左心、脑脊液 (CSF)、阿尔茨海默氏病 (AD) 生物标志物和认知的亚临床改变之间的相互关系。方法对 1244 名认知正常的参与者（平均年龄 = 65.5 岁；43% 女性）进行了多重线性回归，接受超声心动图（左心房 [LA] 和左心室 [LV] 形态或功能参数）和脑脊液 AD 生物标志物测量。研究了 AD 病理的中介效应。使用方差分析 (ANOVA) 和逻辑回归来测试 ATN 类别之间心脏参数的差异。 结果SLA 或 LV 扩大（以直径和体积增加为特征）和 LV 肥厚（室间隔或后壁厚度和心室质量增加）与脑脊液磷酸化 (p)-tau 和总 (t)-tau 水平较高，认知能力较差。 Tau 蛋白病理学介导了心脏认知关系。 2 期和疑似非阿尔茨海默病病理组的心脏参数高于对照组。讨论这些发现表明亚临床心脏变化与 tau 病理和认知密切相关。 左心的各种亚临床改变与认知能力较差有关。 认知正常成人中与 tau 蛋白病理相关的亚临床心脏变化。 Tau 蛋白病理学介导了心脏认知关系。 与 AD 连续体相关的亚临床心脏变化，尤其是第 2 期。 心脏变化的累积放大了对大脑的损害。