Diwu Yanggan (DWYG) is a medicinal food formula that has demonstrated in vivo hepatoprotective properties. However, the mechanisms underlying DWYG's effects against hepatic precancerous lesions have not yet been elucidated. In this study, we aimed to investigate the potential role of DWYG in alleviating pre-cancerous liver lesions and explore the associated mechanisms using a rat model of 2-acetylaminofluorene/partial hepatectomy (2-AAF/PH) induced hepatic precancerous lesions. Our results demonstrated that treatment with Diwu Yanggan significantly reduced the levels of alanine transaminase (ALT) and aspartate transaminase (AST) in the liver compared to the model group. Additionally, alkaline phosphatase (ALP) levels approached those observed in the control group. Meanwhile, the expression of interleukin-6 (IL-6) and hepatocyte growth factor (HGF) was also decreased in the DWYG group. Collectively, our findings suggest that DWYG exhibits significant inhibitory effects on hepatic precancerous lesions in the 2-AAF/PH rat model through modulation of the IL-6/HGFsignaling system.

中文翻译：

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地五养肝对2-AAF/PH大鼠模型肝癌前病变的抑制作用及机制


地物养肝 (DWYG) 是一种药用食品配方，已证明具有体内保肝特性。然而，DWYG 对抗肝癌前病变的作用机制尚未阐明。在本研究中，我们旨在探讨DWYG在减轻肝癌前病变中的潜在作用，并利用2-乙酰氨基芴/部分肝切除术（2-AAF/PH）诱导的肝癌前病变大鼠模型探讨相关机制。我们的结果表明，与模型组相比，地五养肝治疗显着降低了肝脏中丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的水平。此外，碱性磷酸酶（ALP）水平接近对照组。同时，DWYG组中白细胞介素6（IL-6）和肝细胞生长因子（HGF）的表达也有所下降。总的来说，我们的研究结果表明，DWYG 通过调节 IL-6/HGF 信号系统，对 2-AAF/PH 大鼠模型中的肝癌前病变表现出显着的抑制作用。