Gut dysbiosis is closely associated with the burden of chronic kidney disease (CKD), and strategies such as prebiotic supplementation have been suggested to ameliorate CKD and related complications. We hypothesized that prebiotic-soluble dietary fiber (SDF) complexes could ameliorate biochemical parameters, gut microbiota and microbial metabolites of CKD. Here, forty non-dialyzed CKD patients in stage 3 to 5 were randomized to receive either SDF or placebo for 30 days. As expected, SDF intervention reduced serum total cholesterol levels () and plasma interleukin (IL)-8 levels (). No profound changes in the diversity or community structure of the gut microbiota were observed in SDF group, but the composition of the gut microbiota was altered. Moreover, the concentration of propionate of short-chain fatty acids (SCFAs) increased significantly following SDF intervention (). SDF supplementation seems to be a promising strategy to improve inflammation, gut microbiology and derived metabolites.

中文翻译：

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可溶性膳食纤维对 3 至 5 期慢性肾病患者肠道微生物群和衍生代谢物的影响：一项随机对照试验


肠道菌群失调与慢性肾脏病 (CKD) 的负担密切相关，并且已提出补充益生元等策略来改善 CKD 和相关并发症。我们假设益生元可溶性膳食纤维 (SDF) 复合物可以改善 CKD 的生化参数、肠道微生物群和微生物代谢产物。在此，40 名 3 至 5 期非透析 CKD 患者被随机分配接受 SDF 或安慰剂 30 天。正如预期的那样，SDF 干预降低了血清总胆固醇水平 () 和血浆白细胞介素 (IL)-8 水平 ()。 SDF组肠道菌群的多样性或群落结构没有观察到深刻的变化，但肠道菌群的组成发生了改变。此外，SDF 干预后，短链脂肪酸丙酸盐 (SCFA) 的浓度显着增加 ()。补充 SDF 似乎是改善炎症、肠道微生物学和衍生代谢物的一种有前景的策略。