Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other aspects to quality of life. Fatigue is a well-recognised symptom in other inflammatory rheumatological conditions and has been highlighted by people with PMR as a neglected symptom. Methods People with newly diagnosed PMR in English general practice (2012-2014, n = 652) were recruited to a postally-administered cohort study. Surveys included items relating to PMR, general health and well-being. The FACIT-Fatigue questionnaire was included in the survey at diagnosis, 1, 12, 24 and (mean) 61 months follow-ups. Latent class growth analysis was used to define trajectories, based on FACIT-Fatigue scores over time. Trajectories were characterised and compared at baseline and over time. Results 244 people participated at 24 months and 197 at 61 months. Individuals were allocated to one of five fatigue trajectories. Each represented a different average level of fatigue at diagnosis that remained stable over time (Table). From least to most fatigued, trajectory sizes were 111, 122, 211, 133 and 75. Two thirds of the cohort (the three “worst” trajectories) were, on average, more fatigued than reported in the general population. Worse fatigue trajectory was associated with female sex, higher pain and stiffness, higher levels of anxiety, depression, insomnia, and poorer physical function at baseline and throughout. Conclusion Fatigue is common in inflammatory conditions, but under-recognised in PMR. Fatigue severity at the time of diagnosis appears indicative of fatigue levels up to five years later and is associated with a broad range of health constructs at diagnosis and later. This represents an unmet need in a sizable proportion of those with PMR, who may need more help to manage their condition and allow them to return to full function. These findings also present a potential avenue for early identification of those with a poor prognosis related to their PMR. Disclosure S. Muller: None. J. Belcher: None. S. Hider: None. T. Helliwell: None. C.D. Mallen: None.

中文翻译：

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P187 风湿性多肌痛患者的疲劳：一个关键的未满足需求？

背景/目标 风湿性多肌痛 (PMR) 在老年人中很常见，会导致严重的疼痛和僵硬，尤其是肩带和髋带。糖皮质激素治疗通常侧重于减轻疼痛和僵硬，但生活质量还有其他方面。疲劳是其他炎症性风湿病中公认的症状，并且被 PMR 患者强调为被忽视的症状。方法 招募英国全科诊所新诊断的 PMR 患者（2012-2014 年，n = 652）参加一项事后队列研究。调查包括与PMR、一般健康和福祉相关的项目。 FACIT-疲劳问卷包含在诊断时、1、12、24 和（平均）61 个月随访时的调查中。潜在类别增长分析用于根据一段时间内的 FACIT-疲劳评分来定义轨迹。在基线和一段时间内对轨迹进行了表征和比较。结果 24 个月时有 244 人参与，61 个月时有 197 人参与。个人被分配到五种疲劳轨迹之一。每个代表诊断时不同的平均疲劳水平，随着时间的推移保持稳定（表）。从最不疲劳到最疲劳，轨迹大小依次为 111、122、211、133 和 75。平均而言，该群体中三分之二的人（三个“最差”轨迹）比一般人群报告的更疲劳。更糟糕的疲劳轨迹与女性、更高的疼痛和僵硬、更高水平的焦虑、抑郁、失眠以及基线和整个过程中身体功能较差有关。结论 疲劳在炎症性疾病中很常见，但在 PMR 中却未被充分认识。诊断时的疲劳严重程度似乎可以表明五年后的疲劳程度，并且与诊断时及之后的广泛健康状况相关。这代表了相当大比例的 PMR 患者的需求未得到满足，他们可能需要更多帮助来管理自己的病情并让他们恢复全部功能。这些发现还为早期识别与 PMR 相关的预后不良的患者提供了潜在的途径。披露 S. Muller：无。 J·贝尔彻：没有。 S. Hider：没有。 T. 海利威尔：没有。 CD 马伦：没有。