Background Brain magnetic resonance imaging (MRI) of infants with congenital heart disease (CHD) shows brain immaturity assessed via a cortical-based semi-quantitative score. Our primary aim was to develop an infant paralimbic-related subcortical-based semi-quantitative dysmaturation score, a brain dysplasia score (BDS), to detect abnormalities in CHD infants and predict clinical outcomes. Our secondary aim was to validate our BDS in a preclinical mouse model of hypoplastic left heart syndrome.

中文翻译：

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先天性心脏病婴儿旁边缘相关皮质下脑发育不良 MRI 评分的开发和验证

背景患有先天性心脏病 (CHD) 的婴儿的脑磁共振成像 (MRI) 显示，通过基于皮质的半定量评分评估大脑不成熟程度。我们的主要目的是开发一种与婴儿旁边缘相关的基于皮层下的半定量发育不良评分，即脑发育不良评分（BDS），以检测先心病婴儿的异常情况并预测临床结果。我们的次要目标是在左心发育不全综合征的临床前小鼠模型中验证我们的 BDS。