Urinary tract infection (UTI) caused by antimicrobial resistant bacteria is common in dogs leading to serious health impact in pet animal as well as on human health. Understanding the prevalent uropathogens and their drug susceptibility is essential for limiting the antimicrobial resistance through implementation of stewardship policies. In view of this, present study was envisaged to determine the prevalent bacterial uropathogens and their antibiogram from clinical cases of canine UTI. Urine samples were collected from 35 dogs presented with clinical signs of UTI and a total of 27 bacterial isolates were recovered. Among that Escherichia coli was the most predominant isolate followed by Klebsiella aerogenes, Staphylococcus aureus, Proteus mirabilis, Enterococcus sp. and Citrobacter freundii. All isolates were found resistant to one or more 1st line antibiotics recommended by consensus guidelines and 70% of total isolates showed multidrug resistance. Additionally, this study evaluated the weightage of empirical therapy as per the consensus guidelines over antimicrobial susceptibility test guided treatment. Dogs with uncomplicated UTI were selected and categorized into three different groups (n = 6). Group 1 was treated with common empirical choice amoxycillin-clavulanic acid and dogs showed susceptible to ciprofloxacin were kept in Group 2 and treated with ciprofloxacin along with urinary alkalizer disodium hydrogen citrate. Nitrofurantoin susceptible cases were kept in Group 3 and treated with a combination of nitrofurantoin and urinary acidifier ammonium chloride. Therapeutic outcome was evaluated and success rate was higher in Group 2 and 3 than Group 1 suggested that selection of antibiotics with the use of local or institutional antibiogram data is more considerate than acknowledged international guidelines in the existing situation.

由抗菌药物耐药细菌引起的尿路感染 (UTI) 在狗中很常见，会对宠物以及人类健康造成严重影响。了解流行的尿路病原体及其药物敏感性对于通过实施管理政策来限制抗菌药物耐药性至关重要。鉴于此，本研究旨在从犬尿路感染的临床病例中确定常见的细菌性尿路病原体及其抗菌谱。从 35 只出现尿路感染临床症状的狗身上采集了尿液样本，总共回收了 27 种细菌分离株。其中大肠杆菌是最主要的分离株，其次是产气克雷伯菌、金黄色葡萄球菌、奇异变形杆菌、肠球菌。和弗氏柠檬酸杆菌。所有分离株均对共识指南推荐的一种或多种一线抗生素具有耐药性，并且 70% 的总分离株表现出多重耐药性。此外，本研究根据抗菌药物敏感性测试指导治疗的共识指南评估了经验治疗的权重。选择患有简单尿路感染的狗并将其分为三个不同的组（n  = 6）。第1组采用常见的经验选择阿莫西林-克拉维酸进行治疗，而对环丙沙星敏感的狗则保留在第2组中，并用环丙沙星和尿碱化剂柠檬酸氢二钠进行治疗。呋喃妥因敏感病例保留在第3组中，并采用呋喃妥因和尿酸化剂氯化铵联合治疗。对治疗结果进行了评估，第2组和第3组的成功率高于第1组，表明在现有情况下利用当地或机构抗菌谱数据选择抗生素比公认的国际指南更周到。