Introduction Magnetization transfer MRI is sensitive to semi-solid macromolecules, including amyloid beta, and has been used to discriminate Alzheimer’s disease (AD) patients from controls. Here, we utilize an unconstrained 2-pool quantitative MT (qMT) approach that quantifies the longitudinal relaxation rates of free water and semi-solids separately, and investigate its sensitivity to amyloid accumulation in preclinical subjects.

中文翻译：

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无约束定量磁化转移 MRI 对临床前阿尔茨海默氏病淀粉样蛋白负荷的敏感性

简介磁化转移 MRI 对半固体大分子（包括 β 淀粉样蛋白）敏感，已用于区分阿尔茨海默病 (AD) 患者和对照组。在这里，我们利用无约束的 2 池定量 MT (qMT) 方法来量化纵向松弛率分别游离水和半固体，并研究其对临床前受试者中淀粉样蛋白积累的敏感性。