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MRS study on the correlation between frontal GABA+/Glx ratio and abnormal cognitive function in medication-naive patients with narcolepsy
Sleep Medicine ( IF 4.8 ) Pub Date : 2024-04-06 , DOI: 10.1016/j.sleep.2024.04.004 Yanan Gao , Yanting Liu , Sihui Zhao , Yishu Liu , Chen Zhang , Steve Hui , Mark Mikkelsen , Richard A.E. Edden , Xiao Meng , Bing Yu , Li Xiao
Sleep Medicine ( IF 4.8 ) Pub Date : 2024-04-06 , DOI: 10.1016/j.sleep.2024.04.004 Yanan Gao , Yanting Liu , Sihui Zhao , Yishu Liu , Chen Zhang , Steve Hui , Mark Mikkelsen , Richard A.E. Edden , Xiao Meng , Bing Yu , Li Xiao
To compare the GABA+/Glx (glutamate-glutamine) ratio in the prefrontal lobe under non-rapid eye movement sleep between patients with narcolepsy type 1 (NT1) and normal controls and explore the correlation between this difference and abnormal cognitive function, using synchronous electroencephalography-functional magnetic resonance spectroscopy (EEG-fMRS). MRS measurements of GABA+ and Glx concentrations as well as synchronous EEG data were obtained from 26 medication-naive patients with NT1 and 29 sex- and age-matched healthy community volunteers. Cognition was appraised with the Beijing version of the Montreal Cognitive Assessment, and daytime sleepiness was measured using the Epworth Sleepiness Scale. All subjects recorded a 2-week sleep log as well as an overnight polysomnography within 1 week before MR scanning to understand their sleep habits and determine sleep stages. After PSG, they also underwent multiple sleep latency trials. Patient/control group differences in the individual measurements of GABA+ and Glx and the GABA+/Glx ratio and their relationship with cognition were assessed. The GABA+/Glx ratio and GABA + levels of patients with narcolepsy were higher than those of the control group (P＜0.0001 and P = 0.0008, respectively). However, there was no significant difference in Glx levels (P = 0.6360). The GABA+/Glx ratio negatively correlated with abnormal cognitive function (r = −0.6710, P = 0.0002). Moreover, GABA + levels were inversely proportional to rapid eye movement sleep latency (REML) in patients with narcolepsy (r = −0.5019, P = 0.0106). The GABA+/Glx ratio in the prefrontal lobe was higher in NT1 patients during N2 sleep than in normal controls, mainly caused by GABA + levels; this ratio was negatively related to abnormal cognitive function. In addition, GABA + levels were inversely proportional to REML.
更新日期：2024-04-06
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