Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication,Advanced Functional Materials

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Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-04-18 , DOI: 10.1002/adfm.202401654
Shivesh Anand ₁ , Christoph Alexander Müller ₁ , Bjarke Nørrehvedde Jensen ₁ , Menglin Chen _{1,

2}

Affiliation

Biomodulation facilitated by external remote fields, such as those generated by magnetic, optical, and acoustic stimuli, has emerged as an intriguing avenue for tissue biofabrication, owing to their precision and non-invasive characteristics. The active modulation of 3D tissue structures through cellular signaling transductions, encompassing thermo-, mechano-, and electro-transduction, has proven highly effective in inducing spatiotemporally controlled, 4D compositional and functional tissue maturation. This review aims to highlight the current progress and unveil the underlying mechanisms achieved with these leadless strategies. Additionally, it addresses existing challenges and opportunities associated with these distinct approaches. Finally, with a few new directions briefly outlined, it unfolds future perspectives for their continual advancement.

中文翻译：

将偏远地区视为组织生物制造的第四个维度

由外部远程场（例如由磁、光和声刺激产生的场）促进的生物调节，由于其精确性和非侵入性的特性，已成为组织生物制造的一种有趣的途径。事实证明，通过细胞信号转导（包括热转导、机械转导和电转导）主动调节 3D 组织结构对于诱导时空控制的 4D 成分和功能组织成熟非常有效。本次审查旨在强调当前的进展并揭示通过这些无领导策略实现的基本机制。此外，它还解决了与这些不同方法相关的现有挑战和机遇。最后，简要概述了一些新方向，并展示了它们持续发展的未来前景。

更新日期：2024-04-18

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