Treatment of infected wound by simultaneously eliminating bacteria and inducing angiogenesis to promote wound tissue regeneration remains a clinical challenge. Dynamic and reversable hydrogels can adapt to irregular wound beds, which have raised great attention as wound dressings. Herein, a sprayable chitosan-based hydrogel (HPC/CCS/ODex-IGF1) was developed using hydroxypropyl chitosan (HPC), caffeic acid functionalized chitosan (CCS), oxidized dextran (ODex) to crosslink through the dynamic imine bond, which was pH-responsive to the acidic microenvironment and could controllably release insulin growth factor-1 (IGF1). The HPC/CCS/ODex-IGF1 hydrogels not only showed self-healing, self-adaptable and sprayable properties, but also exhibited excellent antibacterial ability, antioxidant property, low-cytotoxicity and angiogenetic activity. In vivo experiments demonstrated that hydrogels promoted tissue regeneration and healing of bacteria-infected wound with a rate of approximately 98.4 % on day 11 by eliminating bacteria, reducing inflammatory and facilitating angiogenesis, demonstrating its great potential for wound dressing.

中文翻译：

---

可喷雾和自愈的基于壳聚糖的水凝胶，通过抗菌、抗炎和血管生成促进感染伤口的愈合

通过同时消除细菌和诱导血管生成以促进伤口组织再生来治疗感染伤口仍然是临床挑战。动态且可逆的水凝胶可以适应不规则的创面床，作为伤口敷料引起了极大的关注。本文利用羟丙基壳聚糖（HPC）、咖啡酸功能化壳聚糖（CCS）、氧化葡聚糖（ODex）通过动态亚胺键交联，开发了一种可喷雾的壳聚糖基水凝胶（HPC/CCS/ODex-IGF1），pH为-对酸性微环境做出反应，并能可控地释放胰岛素生长因子-1（IGF1）。 HPC/CCS/ODex-IGF1水凝胶不仅表现出自修复、自适应和可喷雾特性，而且还表现出优异的抗菌能力、抗氧化能力、低细胞毒性和血管生成活性。体内实验表明，水凝胶通过消除细菌、减少炎症和促进血管生成，促进细菌感染伤口的组织再生和愈合，第11天的愈合率约为98.4%，展示了其作为伤口敷料的巨大潜力。