Cyclodextrins (CDs) are essential in the pharmaceutical industry and have long been used as food and pharmaceutical additives. CD-based interlocked molecules, such as rotaxanes, polyrotaxanes, catenanes, and polycatenanes, have been synthesized and have attracted considerable attention in supramolecular chemistry. Among them, CD polyrotaxanes have been employed as slide-ring materials and biomaterials. CD polycatenanes are new materials; therefore, to date, no examples of applied research on CD polycatenanes have been reported. Consequently, we expect that applied research on CD polycatenanes will accelerate in the future. This review article summarizes the syntheses and structural analyses of CD polyrotaxanes and polycatenanes to facilitate their applications in the pharmaceutical industry. We believe that this review will promote further research on CD-based interlocked molecules.

中文翻译：

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用于超分子药物科学的环糊精基聚轮烷和聚链烷的合成

环糊精 (CD) 在制药工业中至关重要，长期以来一直被用作食品和药物添加剂。基于环糊精的连锁分子，如轮烷、聚轮烷、链烷和聚链烷已被合成，并在超分子化学领域引起了相当大的关注。其中，CD聚轮烷已被用作滑环材料和生物材料。 CD聚环烷是新材料；因此，迄今为止，还没有关于CD聚链烷的应用研究实例的报道。因此，我们预计环糊精聚链烷的应用研究未来将会加速。本文总结了CD聚轮烷和聚环烷的合成和结构分析，以促进其在制药行业的应用。我们相信这篇综述将促进基于环糊精的连锁分子的进一步研究。