The study aimed to explore the impact of a novel near-infrared LED (nNIR) with an extended spectrum on skin enhancement and hair growth. Various LED sources, including White and nNIRs, were compared across multiple parameters: cytotoxicity, adenosine triphosphate (ATP) synthesis, reactive oxygen species (ROS) reduction, skin thickness, collagen synthesis, collagenase expression, and hair follicle growth. Experiments were conducted on human skin cells and animal models. Cytotoxicity, ATP synthesis, and ROS reduction were evaluated in human skin cells exposed to nNIRs and Whites. LED irradiation effects were also studied on a UV-induced photoaging mouse model, analyzing skin thickness, collagen synthesis, and collagenase expression. Hair growth promotion was examined as well. Results revealed both White and nNIR were non-cytotoxic to human skin cells. nNIR enhanced ATP and collagen synthesis while reducing ROS levels, outperforming the commonly used 2chip LEDs. In the UV-induced photoaging mouse model, nNIR irradiation led to reduced skin thickness, increased collagen synthesis, and lowered collagenase expression. Additionally, nNIR irradiation stimulated hair growth, augmented skin thickness, and increased hair follicle count. In conclusion, the study highlighted positive effects of White and nNIR irradiation on skin and hair growth. However, nNIR exhibited superior outcomes compared to White. Its advancements in ATP content, collagen synthesis, collagenase inhibition, and hair growth promotion imply increased ATP synthesis activity. These findings underscore nNIR therapy’s potential as an innovative and effective approach for enhancing skin and promoting hair growth.

该研究旨在探索具有扩展光谱的新型近红外 LED (nNIR) 对皮肤增强和毛发生长的影响。对包括白光和 nNIR 在内的各种 LED 光源的多个参数进行了比较：细胞毒性、三磷酸腺苷 (ATP) 合成、活性氧 (ROS) 减少、皮肤厚度、胶原蛋白合成、胶原酶表达和毛囊生长。在人类皮肤细胞和动物模型上进行了实验。在暴露于 nNIR 和 Whites 的人类皮肤细胞中评估了细胞毒性、ATP 合成和 ROS 减少。还在紫外线诱导的光老化小鼠模型上研究了 LED 照射效果，分析了皮肤厚度、胶原蛋白合成和胶原酶表达。还检查了头发生长促进作用。结果显示 White 和 nNIR 对人类皮肤细胞均无细胞毒性。 nNIR 增强了 ATP 和胶原蛋白的合成，同时降低了 ROS 水平，其性能优于常用的 2chip LED。在紫外线诱导的光老化小鼠模型中，nNIR 照射导致皮肤厚度减少、胶原蛋白合成增加并降低胶原酶表达。此外，近红外辐射还能刺激毛发生长、增加皮肤厚度和增加毛囊数量。总之，该研究强调了白色和近红外辐射对皮肤和毛发生长的积极影响。然而，与 White 相比，nNIR 表现出更好的结果。它在 ATP 含量、胶原蛋白合成、胶原酶抑制和促进毛发生长方面的进步意味着 ATP 合成活性的增加。这些发现强调了 nNIR 疗法作为一种创新且有效的方法来增强皮肤和促进毛发生长的潜力。