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An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics
Chemical Communications ( IF 4.9 ) Pub Date : 2024-04-18 , DOI: 10.1039/d4cc00431k
Qi Wang 1 , Ruoqing Wang 1 , Xiaoyuan Wang 1 , Mingxuan Fu 1 , Yicong Gao 1 , Jianfeng Feng 1 , Renyong Geng 2 , Zhen Yuan 3 , Quli Fan 1 , Feng Lu 1
Affiliation  

A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push–pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS generation, showing encouraging therapeutic outcomes for hypoxic tumors.

中文翻译:

一种发射 NIR-II 的 I 型光敏剂,用于有效的缺氧肿瘤光治疗

合成了一种具有强推拉效应和良好平面π共轭结构的小分子NIR-II I型光敏剂(IT-IC)。 IT-IC NPs表现出强光吸收、出色的NIR-II荧光发射、出色的光热转换和高效的I/II型ROS生成,对缺氧肿瘤显示出令人鼓舞的治疗效果。
更新日期:2024-04-18
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