Neurological disorders are the leading cause of a large number of mortalities and morbidities. Nitrogen heterocyclic compounds have been pivotal in exhibiting wide array of therapeutic applications. Among them, tetrazole is a ubiquitous class of organic heterocyclic compounds that have attracted much attention because of its unique structural and chemical properties, and a wide range of pharmacological activities comprising anti-convulsant effect, antibiotic, anti-allergic, anti-hypertensive to name a few. Owing to significant chemical and biological properties, the present review aimed at highlighting the recent advances in tetrazole derivatives with special emphasis on their role in the management of neurological diseases. Besides, in-depth structure-activity relationships, molecular docking studies, and associated modes of action of tetrazole derivatives evident in in vitro, in vivo preclinical, and clinical studies have been discussed.

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四唑衍生物在神经系统疾病治疗中的应用：合成和药理学方面的最新进展

神经系统疾病是大量死亡和发病的主要原因。氮杂环化合物在展示广泛的治疗应用方面发挥着关键作用。其中，四唑是一类普遍存在的有机杂环化合物，因其独特的结构和化学性质以及广泛的药理活性而备受关注，包括抗惊厥、抗菌、抗过敏、抗高血压等。一些。由于四唑衍生物具有显着的化学和生物学特性，本综述旨在强调四唑衍生物的最新进展，特别强调它们在神经系统疾病治疗中的作用。此外，还讨论了四唑衍生物在体外、体内临床前和临床研究中的深入构效关系、分子对接研究和相关作用模式。