Photochemical 3D printing is a rapidly advancing technology for the fabrication of intricate structures with adjustable mechanical properties, and is also finding increasing interest in biomaterial scaffolds and personalized medicine. Currently, mostly polyester and polycarbonate-based photopolymers are used, but these are limited in their scope of degradation, for example, often being too slow for applications like tissue scaffolds. Herein, we design and develop novel amino acid phosphoramidite-based vinyl ester and carbonate resins. Model studies demonstrate hydrolysis to the corresponding amino acid and phosphate, the rate of which can be tuned by varying the amino acid components. We then transfer this to the design of photopolymer resins with tailored degradation rate profiles, ranging from days to several months, under simulated physiological conditions. 3D printing capabilities are demonstrated using a desktop digital light processing (DLP) printer and multiphotolithography (MPL). Cytocompatibility, cell viability and osteogenic differentiation studies indicate the potential of these newly developed biodegradable scaffolds for bone regeneration applications. Overall, this research presents a promising approach to overcome existing limitations in biodegradable photopolymer materials for 3D printing in biomedical applications.

中文翻译：

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用于通过乙烯基酯和碳酸乙烯酯功能化氨基酸-氨基磷酸酯进行光化学 3D 打印的可生物降解树脂

光化学 3D 打印是一种快速发展的技术，用于制造具有可调节机械性能的复杂结构，并且人们对生物材料支架和个性化医疗也越来越感兴趣。目前，主要使用基于聚酯和聚碳酸酯的光聚合物，但它们的降解范围有限，例如，对于组织支架等应用来说通常太慢。在此，我们设计和开发了新型氨基酸亚磷酰胺基乙烯基酯和碳酸酯树脂。模型研究证明水解成相应的氨基酸和磷酸盐，其速率可以通过改变氨基酸成分来调节。然后，我们将其转移到光聚合物树脂的设计中，在模拟生理条件下，具有定制的降解率曲线，从几天到几个月不等。使用桌面数字光处理 (DLP) 打印机和多重光刻 (MPL) 演示了 3D 打印功能。细胞相容性、细胞活力和成骨分化研究表明这些新开发的可生物降解支架在骨再生应用中的潜力。总的来说，这项研究提出了一种有前途的方法来克服生物医学应用中 3D 打印的可生物降解光聚合物材料的现有限制。