The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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片剂纳米医学：从当前情况到开发未来医学

传统治疗方法的局限性在基于纳米技术的医学制剂（称为纳米医学）的开发中普遍存在。纳米医学是一种先进药物，通常由嵌入可生物降解或生物相容性纳米材料配方中的治疗剂组成。在纳米医学方法中，片剂（口服）纳米医学仍在开发中。在片剂纳米药物中，纳米制剂和胃肠道复杂环境之间的动态相互作用发挥着关键作用，特别是增强了对管腔、粘膜和上皮细胞的影响。在这项工作中，我们记录了纳米制剂对片剂纳米医学发展的前景和机遇。该综述还揭示了将纳米药物整合到片剂配方中的概念，这有助于药物、生物分子和制剂从配方中的受控释放，以实现更好的治疗反应。最后，尝试探讨噬菌体、益生菌、寡核苷酸片状纳米药物以及纳米药物与显像剂的结合（即纳米治疗学）等纳米医学技术的当前趋势。