Functional group transfer strategies employing bench-stable and convenient-to-handle surrogates to replace highly toxic and hazardous reagents unlock novel synthetic pathways with the prospect of green and sustainable chemistry. The development of such synthetic tools that extend beyond the use of traditional and unsustainable chemicals is highly desirable in both academic and industrial research. In this perspective, we highlight recent developments and representative progress in the area of functional group transfer strategies with respect to different types of transfer modes, such as transition-metal-catalyzed, free-radical, ionic, as well as radical-ionic transfer. Furthermore, mechanistic considerations of functional group transfer chemistry, as well as future opportunities, challenges, and efforts, are also discussed.

采用稳定且易于处理的替代物的官能团转移策略来替代剧毒和危险的试剂，开启了具有绿色和可持续化学前景的新型合成途径。学术和工业研究都非常希望开发这种超越传统和不可持续化学品使用的合成工具。从这个角度来看，我们重点介绍了官能团转移策略领域关于不同类型转移模式的最新发展和代表性进展，例如过渡金属催化、自由基、离子以及自由基-离子转移。此外，还讨论了官能团转移化学的机理考虑，以及未来的机遇、挑战和努力。