Luminescent supraparticles of colloidal semiconductor nanocrystals can act as microscopic lasers and are hugely attractive for biosensing, imaging, and drug delivery. However, biointerfacing these to increase functionality while retaining their main optical properties remains an unresolved challenge. Here, we propose and demonstrate red-emitting, silica-coated CdS_xSe_1−x/ZnS colloidal quantum dot supraparticles functionalized with a biotinylated photocleavable ligand. The success of each step of the synthesis is confirmed by scanning electron microscopy, energy dispersive X-ray and Fourier transform infrared spectroscopy, ζ-potential, and optical pumping measurements. The capture and release functionality of the supraparticle system is proven by binding to a neutravidin functionalized glass slide and subsequently cleaving off after UV-A irradiation. The biotinylated supraparticles still function as microlasers; e.g., a 9 μm diameter supraparticle has oscillating modes around 625 nm at a threshold of 58 mJ/cm². This work is a first step toward using supraparticle lasers as enhanced labels for bionano applications.

中文翻译：

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生物素化光裂解半导体胶体量子点超粒子微型激光器

胶体半导体纳米晶体的发光超粒子可以充当微型激光器，对于生物传感、成像和药物输送具有巨大的吸引力。然而，将这些生物界面连接起来以增加功能，同时保留其主要光学特性仍然是一个尚未解决的挑战。在这里，我们提出并演示了用生物素化光裂解配体功能化的发红光、二氧化硅涂层的CdS _x Se _{1 -x} /ZnS胶体量子点超粒子。扫描电子显微镜、能量色散 X 射线和傅里叶变换红外光谱、 z 电位和光泵浦测量证实了合成每个步骤的成功。通过与中性亲和素功能化载玻片结合并随后在 UV-A 照射后裂解，证明了超颗粒系统的捕获和释放功能。生物素化的超粒子仍然具有微型激光器的功能；例如，直径为9 μm的超粒子在阈值为58 mJ/cm ²时具有约625 nm的振荡模式。这项工作是使用超粒子激光器作为生物纳米应用的增强标签的第一步。