MucR protein: Three decades of studies have led to the identification of a new H‐NS‐like protein,Molecular Microbiology

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MucR protein: Three decades of studies have led to the identification of a new H‐NS‐like protein
Molecular Microbiology ( IF 2.6 ) Pub Date : 2024-04-15 , DOI: 10.1111/mmi.15261
Ilaria Baglivo ₁ , Gaetano Malgieri ₁ , Roy Martin Roop ₂ , Ian S Barton ₂ , Xindan Wang ₃ , Veronica Russo ₄ , Luciano Pirone ₅ , Emilia M Pedone ₅ , Paolo V Pedone ₁

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MucR belongs to a large protein family whose members regulate the expression of virulence and symbiosis genes in α‐proteobacteria species. This protein and its homologs were initially studied as classical transcriptional regulators mostly involved in repression of target genes by binding their promoters. Very recent studies have led to the classification of MucR as a new type of Histone‐like Nucleoid Structuring (H‐NS) protein. Thus this review is an effort to put together a complete and unifying story demonstrating how genetic and biochemical findings on MucR suggested that this protein is not a classical transcriptional regulator, but functions as a novel type of H‐NS‐like protein, which binds AT‐rich regions of genomic DNA and regulates gene expression.

中文翻译：

MucR 蛋白：三十年的研究已经确定了一种新的 H-NS 样蛋白

MucR 属于一个大型蛋白质家族，其成员调节 α 变形菌门物种中毒力和共生基因的表达。这种蛋白质及其同源物最初被研究为经典转录调节因子，主要通过结合其启动子参与靶基因的抑制。最近的研究导致 MucR 被归类为一种新型的组蛋白样核结构（H-NS）蛋白。因此，本综述旨在将一个完整而统一的故事放在一起，证明 MucR 的遗传和生化发现如何表明该蛋白质不是经典的转录调节因子，而是作为一种新型的 H-NS 样蛋白发挥作用，它结合基因组 DNA 中富含 AT 的区域并调节基因表达。

更新日期：2024-04-15

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