Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women were randomized to receive or placebo or Resveratrol (150 mg per day) for three months preceding the ovarian stimulation (OS). All patients were stimulated with a starting dose of recombinant FSH ranging between 150 and 300 IU according to age and ovarian reserve. GnRH antagonist flexible protocol was adopted for pituitary suppression. Triggering was performed with urinary hCG (10.000 IU). The study was conducted between January 2019 and December 2022 with aa total of 37 cases and 33 controls were recruited. No statistically significant differences in the number of oocytes retrieved, biochemical pregnancy, clinical pregnancy and live birth rates were observed between women treated with resveratrol and control group. A statistically significant increase in the follicle output rate (FORT) and follicle-to oocyte index (FOI) was observed in women treated with resveratrol-based nutraceutical (0.92 versus 0.77 [p = 0.02], and 0.77 versus 0.64 [p = 0.006], respectively). Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS in advanced reproductive age women.

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白藜芦醇对体外受精结果的影响：一项探索性随机安慰剂对照试验

白藜芦醇是一种存在于植物和红酒中的天然多酚化合物，具有许多潜在的健康益处。这种化合物具有多种抗炎和抗肿瘤特性，可以改善细胞线粒体活性。该试验旨在评估补充白藜芦醇对卵巢储备良好（AMH > 1.2 ng/ml）的 35 岁以上女性 IVF 结果的影响。女性在卵巢刺激 (OS) 前三个月随机接受安慰剂或白藜芦醇（每天 150 毫克）。根据年龄和卵巢储备情况，所有患者均接受 150 至 300 IU 范围内的重组 FSH 起始剂量的刺激。采用GnRH拮抗剂灵活方案进行垂体抑制。使用尿 hCG (10.000 IU) 进行触发。该研究于2019年1月至2022年12月期间进行，共招募了37名病例和33名对照者。在接受白藜芦醇治疗的女性与对照组之间，在取出的卵母细胞数量、生化妊娠、临床妊娠和活产率方面没有观察到统计学上的显着差异。在接受白藜芦醇营养保健品治疗的女性中，观察到卵泡排出率 (FORT) 和卵泡卵母细胞指数 (FOI) 显着增加（0.92 与 0.77 [p = 0.02]，以及 0.77 与 0.64 [p = 0.006]） ， 分别）。这项研究的初步结果表明，白藜芦醇预处理可能会提高卵巢对外源性 FSH 的敏感性，从而可能降低高龄育龄女性对 OS 反应低下的风险。