Neural tissue engineering is a sub-field of tissue engineering that develops neural tissue. Damaged central and peripheral nervous tissue can be fabricated with a suitable scaffold printed with biomaterials. These scaffolds promote cell growth, development, and migration, yet they vary according to the biomaterial and scaffold printing technique, which determine the physical and biochemical properties. The physical and biochemical properties of scaffolds stimulate diverse signalling pathways, such as Wnt, NOTCH, Hedgehog, and ion channels- mediated pathways to promote neuron migration, elongation and migration. However, neurotransmitters like dopamine, acetylcholine, gamma amino butyric acid, and other signalling molecules are critical in neural tissue engineering to tissue fabrication. Thus, this review focuses on neural tissue regeneration with a tissue engineering approach highlighting the signalling pathways. Further, it explores the interaction of the scaffolds with the signalling pathways for generating neural tissue.

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促进神经组织生长的分子和细胞信号传导途径 - 组织工程方法

神经组织工程是发育神经组织的组织工程的一个子领域。受损的中枢和周围神经组织可以用印有生物材料的合适支架来制造。这些支架促进细胞生长、发育和迁移，但它们根据生物材料和支架打印技术而变化，而生物材料和支架打印技术决定了物理和生化特性。支架的物理和生化特性刺激多种信号通路，如Wnt、NOTCH、Hedgehog和离子通道介导的通路，促进神经元迁移、伸长和迁移。然而，多巴胺、乙酰胆碱、γ-氨基丁酸和其他信号分子等神经递质在神经组织工程和组织制造中至关重要。因此，本综述的重点是通过组织工程方法强调信号通路的神经组织再生。此外，它还探索了支架与生成神经组织的信号通路的相互作用。