Traditional sample preparation techniques based on liquid-liquid extraction (LLE) or solid phase extraction (SPE) often suffer from a major error due to the matrix effects caused by significant co-extraction of matrix components. The implementation of a modern extraction technique such as solid phase microextraction (SPME) was aimed at reducing analysis time and the use of organic solvents, as well as eliminating pre-analytical and analytical errors. Solid phase microextraction (SPME) is an innovative technique for extracting low molecular weight compounds (less than 1500 Da) from highly complex matrices including biological matrices. It has a wide range of applications in various types of analysis including pharmaceutical, metabolomic, proteomic and clinical. SPME has a number of advantages over other extraction techniques. Among the most important are low environmental impact, the ability to sampling and preconcentration the analytes in one step, simple automation, and the ability to extract multiple analytes simultaneously. It is expected to become in the future another method for cell cycle researches. Numerous available literature sources prove that solid phase microextraction can be a future technique in many scientific fields including pharmaceutical sciences. This paper provides literature review of trends in SPME coatings and pharmacological applications

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固相微萃取——药理学和涂料趋势的未来技术

基于液液萃取 (LLE) 或固相萃取 (SPE) 的传统样品制备技术经常会因基质成分的显着共萃取而引起的基质效应而遭受重大误差。固相微萃取 (SPME) 等现代萃取技术的实施旨在减少分析时间和有机溶剂的使用，并消除分析前和分析误差。固相微萃取 (SPME) 是一种从高度复杂的基质（包括生物基质）中提取低分子量化合物（小于 1500 Da）的创新技术。它在各种类型的分析中具有广泛的应用，包括药物、代谢组学、蛋白质组学和临床。与其他萃取技术相比，固相微萃取 (SPME) 具有许多优点。其中最重要的是环境影响低、一步采样和预浓缩分析物的能力、简单的自动化以及同时提取多种分析物的能力。有望成为未来细胞周期研究的另一种方法。大量可用的文献来源证明，固相微萃取可以成为包括制药科学在内的许多科学领域的未来技术。本文提供了 SPME 涂层和药理学应用趋势的文献综述