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Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2024-04-14 , DOI: 10.1002/adma.202401619 Kaizheng Feng 1 , Guancheng Wang 1 , Shi Wang 1 , Jingyuan Ma 1 , Haoan Wu 1 , Ming Ma 1 , Yu Zhang 1
Advanced Materials ( IF 27.4 ) Pub Date : 2024-04-14 , DOI: 10.1002/adma.202401619 Kaizheng Feng 1 , Guancheng Wang 1 , Shi Wang 1 , Jingyuan Ma 1 , Haoan Wu 1 , Ming Ma 1 , Yu Zhang 1
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Although nanozymes have drawn great attention over the past decade, the activities of peroxidase-like, oxidase-like, and catalase-like nanozymes are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on the pH-related catalytic mechanisms of nanozymes together with the methods to overcome this limitation is in need. In this review, various nanozymes exhibiting pH-dependent catalytic activities are collected and the root causes for their pH dependence are comprehensively analyzed. Subsequently, regulatory concepts including catalytic environment reconstruction and direct catalytic activity improvement to break this pH restriction are summarized. Moreover, applications of pH-independent nanozymes in sensing, disease therapy, and pollutant degradation are overviewed. Finally, current challenges and future opportunities on the development of pH-independent nanozymes are suggested. It is anticipated that this review will promote the further design of pH-independent nanozymes and broaden their application range with higher efficiency.
中文翻译：
打破纳米酶的pH限制：机制、方法和应用
尽管纳米酶在过去十年中引起了人们的广泛关注，但类过氧化物酶、类氧化酶和类过氧化氢酶纳米酶的活性往往依赖于pH且机制难以捉摸，这在很大程度上限制了它们的应用。因此，有必要对纳米酶与pH相关的催化机制以及克服这一限制的方法进行系统的讨论。在这篇综述中，收集了各种表现出 pH 依赖性催化活性的纳米酶，并全面分析了其 pH 依赖性的根本原因。随后，总结了催化环境重建和直接催化活性改进等监管概念，以打破这种pH限制。此外，还概述了与 pH 无关的纳米酶在传感、疾病治疗和污染物降解方面的应用。最后，提出了开发不依赖于 pH 的纳米酶的当前挑战和未来机遇。预计本次综述将促进pH无关纳米酶的进一步设计，并以更高的效率拓宽其应用范围。
更新日期：2024-04-14
中文翻译：
打破纳米酶的pH限制：机制、方法和应用
尽管纳米酶在过去十年中引起了人们的广泛关注，但类过氧化物酶、类氧化酶和类过氧化氢酶纳米酶的活性往往依赖于pH且机制难以捉摸，这在很大程度上限制了它们的应用。因此，有必要对纳米酶与pH相关的催化机制以及克服这一限制的方法进行系统的讨论。在这篇综述中，收集了各种表现出 pH 依赖性催化活性的纳米酶，并全面分析了其 pH 依赖性的根本原因。随后，总结了催化环境重建和直接催化活性改进等监管概念，以打破这种pH限制。此外，还概述了与 pH 无关的纳米酶在传感、疾病治疗和污染物降解方面的应用。最后，提出了开发不依赖于 pH 的纳米酶的当前挑战和未来机遇。预计本次综述将促进pH无关纳米酶的进一步设计，并以更高的效率拓宽其应用范围。
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