Inexpensive cobalt‐catalyzed, pivalic acid‐assisted oxidative C‐H functionalization of benzimidates or NH‐benzaldimines with ynamides is presented, providing an access to 3‐aminoisoquinoline derivatives. The procedure is compatible with various substrates featuring alkyl, alkoxy, acyl or halogen as substituents, heteroaryl structures, and diverse ynamides. The reaction has been scaled up, with subsequent transformation of the yielded products. Control experiments and mechanistic investigations corroborate the regioselectivity of this conversion, positioning the amine group proximal to the nitrogen atom in isoquinolines.

中文翻译：

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钴催化苯亚胺酯或 NH-苯亚胺与酰胺的环化：1-烷氧基-和 1-烷基-3-氨基异喹啉的合成

提出了廉价的钴催化、新戊酸辅助的苯甲亚胺酯或 NH-苯甲醛亚胺与 ynamides 的氧化 C-H 官能化，提供了获得 3-氨基异喹啉衍生物的途径。该程序与以烷基、烷氧基、酰基或卤素作为取代基、杂芳基结构和各种炔酰胺为特征的各种底物兼容。该反应已扩大规模，随后对所得产物进行了转化。对照实验和机理研究证实了这种转化的区域选择性，将胺基定位在异喹啉中最接近氮原子的位置。