Malignant melanoma incidence has been rising steadily in recent years, gravely endangering people's quality of life. One of several natural colors that have been demonstrated to have this potential is fucoxanthin (FX), a natural pigment made from brown algae. The FX has been shown to have anti-tumor properties. But there are still a lot of questions concerning its working effects. In this study, we evaluated the effect of FX on human malignant melanoma cells (A375) and keratinocytes (HaCaT) and evaluated the model and analyzed their apoptosis mechanisms. FX promoted intracellular reactive oxygen production, mitochondrial membrane potential loss, and DNA degradation. FX simultaneously regulated the MAPK signaling pathway, which is linked to both inflammation and apoptosis. Our lipidomics findings demonstrated that FX controls abnormalities in lipid metabolism and disturbs membrane architecture. These findings supported FX's ability to intervene melanoma growth, which could provide new information on FX functional foods.

中文翻译：

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人恶性黑色素瘤细胞（A375）和角质形成细胞（HaCaT）构建的细胞模型中岩藻黄质抑制黑色素瘤的机制


近年来，恶性黑色素瘤发病率持续上升，严重危害人们的生活质量。岩藻黄质 (FX) 是已被证明具有这种潜力的几种天然色素之一，它是一种由褐藻制成的天然色素。 FX 已被证明具有抗肿瘤特性。但其工作效果仍存在不少疑问。在本研究中，我们评估了FX对人恶性黑色素瘤细胞（A375）和角质形成细胞（HaCaT）的影响，并评估了模型并分析了它们的凋亡机制。 FX 促进细胞内活性氧的产生、线粒体膜电位损失和 DNA 降解。 FX 同时调节与炎症和细胞凋亡相关的 MAPK 信号通路。我们的脂质组学研究结果表明，FX 控制脂质代谢异常并扰乱膜结构。这些发现支持 FX 干预黑色素瘤生长的能力，这可以提供有关 FX 功能性食品的新信息。