The development of efficient, accurate, and high-throughput technology for gut microbiota sensing holds great promise in the maintenance of health and the treatment of diseases. Herein, we developed a rapid fluorescent sensor array based on surface-engineered silver nanoparticles (AgNPs) and vancomycin-modified gold nanoclusters (AuNCs@Van) for gut microbiota sensing. By controlling the surface of AgNPs, the recognition ability of the sensor can be effectively improved. The sensor array was used to successfully discriminate six gut-derived bacteria, including probiotics, neutral, and pathogenic bacteria and even their mixtures. Significantly, the sensing system has also been successfully applied to classify healthy individuals and colorectal cancer (CRC) patients rapidly and accurately within 30 min, demonstrating its clinically relevant specificity.

中文翻译：

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用于识别肠道微生物群和监测结直肠癌的表面介导荧光传感器阵列

高效、准确和高通量的肠道微生物群传感技术的发展在维护健康和治疗疾病方面具有广阔的前景。在此，我们开发了一种基于表面工程银纳米颗粒（AgNP）和万古霉素修饰的金纳米簇（AuNCs@Van）的快速荧光传感器阵列，用于肠道微生物群传感。通过控制AgNPs的表面，可以有效提高传感器的识别能力。该传感器阵列被用来成功区分六种肠道来源的细菌，包括益生菌、中性细菌和病原菌，甚至它们的混合物。值得注意的是，该传感系统还成功应用于在 30 分钟内快速准确地对健康个体和结直肠癌 (CRC) 患者进行分类，证明了其临床相关特异性。