Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are promising tumor treatments mediated by reactive oxygen species (ROS), which have the advantages of being minimally invasive. However, the hypoxia of tumor microenvironment and poor target ability often reduce the therapeutic effect. Here we propose a tumor targeted nanoplatform PCN‐224@Co3O4‐HA for enhanced PDT and synergistic CDT, constructed by hyaluronate‐modified Co3O4 nanoparticles decorated metal‐organic framework PCN‐224. Co3O4 can catalyze the decomposition of highly expressed H2O2 in tumor cells to produce oxygen and alleviate the problem of hypoxia. It can also produce hydroxyl radicals according to the Fenton‐like reaction for chemical dynamic therapy, significantly improving the therapeutic effect. The cell survival experiment showed that after in vitro treatment, 4T1 and MCF‐7 cancer cells died in a large area under the anaerobic state, while the survival ability of normal cell LO2 was nearly unchanged. This result effectively indicated that PCN‐224@Co3O4‐HA could effectively relieve tumor hypoxia and improve the effect of PDT and synergistic CDT. Cell uptake experiments showed that PCN‐224@Co3O4‐HA had good targeting properties and could effectively aggregate in tumor cells. In vivo experiments on mice, PCN‐224@Co3O4‐HA presented reliable biosafety performance, and can cooperate with PDT and CDT therapy to prevent the growth of tumor.

中文翻译：

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金属有机框架 PCN-224 组合氧化钴纳米粒子用于缓解缺氧和协同光动力/化学动力治疗

光动力疗法（PDT）和化学动力疗法（CDT）是活性氧（ROS）介导的有前途的肿瘤治疗方法，具有微创的优点。然而，肿瘤微环境的缺氧和靶向能力差往往会降低治疗效果。在这里，我们提出了一种用于增强 PDT 和协同 CDT 的肿瘤靶向纳米平台 PCN-224@Co3O4-HA，由透明质酸修饰的 Co3O4 纳米颗粒装饰金属有机框架 PCN-224 构建。 Co3O4可以催化肿瘤细胞中高表达的H2O2分解产生氧气，缓解缺氧问题。它还可以根据类芬顿反应产生羟基自由基进行化学动力治疗，显着提高治疗效果。细胞存活实验表明，体外处理后，4T1和MCF-7癌细胞在厌氧状态下大面积死亡，而正常细胞LO2的存活能力几乎没有变化。这一结果有效表明PCN-224@Co3O4-HA可以有效缓解肿瘤缺氧，提高PDT和协同CDT的效果。细胞摄取实验表明PCN-224@Co3O4-HA具有良好的靶向性，能够在肿瘤细胞中有效聚集。在小鼠体内实验中，PCN-224@Co3O4-HA表现出可靠的生物安全性能，可以配合PDT和CDT治疗阻止肿瘤的生长。