The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer’s disease (AD)—a neurodegenerative condition caused by the accumulation of amyloid beta and hyperphosphorylation of tau proteins. Multiple studies have found dependence between these two conditions. Patients with Alzheimer’s disease have a greater risk of SARS-CoV-2 infection due to increased levels of angiotensin-converting enzyme 2 (ACE2), and the infection itself promotes amyloid beta generation which enhances the risk of AD. Also, the molecular pathways are alike—misregulations in folate-mediated one-carbon metabolism, a deficit of Cq10, and disease-associated microglia. Medical imaging in both of these diseases shows a decrease in the volume of gray matter, global brain size reduction, and hypometabolism in the parahippocampal gyrus, thalamus, and cingulate cortex. In some studies, a similar approach to applied medication can be seen, including the use of amino adamantanes and phenolic compounds of rosemary. The significance of these connections and their possible application in medical practice still needs further study but there is a possibility that they will help to better understand long COVID.

长期的新冠病毒（冠状病毒病）是严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）感染后的一种多系统疾病，是广泛存在的问题之一。它的一些症状会影响神经系统，类似于阿尔茨海默病 (AD) 的症状，阿尔茨海默病是一种由 β 淀粉样蛋白积累和 tau 蛋白过度磷酸化引起的神经退行性疾病。多项研究发现这两种情况之间存在依赖性。由于血管紧张素转换酶 2 (ACE2) 水平升高，阿尔茨海默病患者感染 SARS-CoV-2 的风险更大，而且感染本身会促进β淀粉样蛋白的生成，从而增加 AD 风险。此外，分子途径也很相似——叶酸介导的一碳代谢的失调、Cq10 的缺乏以及与疾病相关的小胶质细胞。这两种疾病的医学影像显示灰质体积减少，大脑整体尺寸缩小，海马旁回、丘脑和扣带皮层代谢低下。在一些研究中，可以看到类似的应用药物方法，包括使用氨基金刚烷和迷迭香酚类化合物。这些联系的重要性及其在医疗实践中的可能应用仍需要进一步研究，但它们有可能有助于更好地了解长期的新冠病毒。