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CXCR4 Antagonist in HPV5-Associated Perianal Squamous-Cell Carcinoma
The New England Journal of Medicine ( IF 158.5 ) Pub Date : 2024-04-11 , DOI: 10.1056/nejmc2213180
Viviana Marin-Esteban 1 , Lucie Molet 1 , Marta Laganà 1 , Dragos Ciocan 2 , Clément Dominguez-Lafage 3 , Nagham Alouche 3 , Julie Nguyen 3 , Carmen Gallego 3 , Françoise Mercier-Nomé 3 , Agnieszka Jaracz-Ros 3 , Blandine Beaupain 4 , Jérôme Bouligand 5 , Alexis Proust 6 , Christophe Habib 6 , Rémy A. Bonnin 5 , Delphine Girlich 5 , Fanny Fouyssac 7 , Jean-Luc Schmutz 7 , Anne-Claire Bursztejn 7 , Christine Bellanné-Chantelot 8 , Emmanuelle Bourrat 9 , Michael Herfs 10 , Marion Espéli 11 , Karl Balabanian 11 , Géraldine Schlecht-Louf 3 , Jean Donadieu 4 , Françoise Bachelerie 12 , Claire Deback 12
Affiliation  

WHIM-like syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis) developed in a patient with gain of CXCR4 function. Plerixafor, a CXCR4 antagonist, led to symptom reduction.

中文翻译:

CXCR4 拮抗剂治疗 HPV5 相关肛周鳞状细胞癌

CXCR4 功能获得的患者出现了 WHIM 样综合征(疣、低丙种球蛋白血症、感染和骨髓缺乏症)。 Plerixafor 是一种 CXCR4 拮抗剂,可减轻症状。
更新日期:2024-04-11
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