Hydrogel wound dressings are important medical supplies used to promote healing, absorb wound exudates, and keep a local moist environment around wounds. In this work, longan seed extract (LSE)-loaded alginate (Alg)/chitosan (CS) beads embedded in gelatin (Gel) and quaternized chitosan (QCS) hydrogels were fabricated to sustain the release of LSE and use as wound dressing materials. The effect of embedding beads and crosslinking concentration on the properties of hydrogels was investigated. SEM images showed the interconnected porous structure of the hydrogels. The mechanical properties, swelling, and weight loss of the hydrogels were improved by increasing crosslinking concentration and embedding beads. Hydrogel systems successfully improved the controlled release of LSE, showed lower cytotoxicity, and supported cell migration with 29% wound closure. Therefore, the embedding of LSE-loaded Alg/CS beads into the hydrogels exhibits promising potential for enhancing the characteristics of the hydrogels and sustaining the controlled release of bioactive components, so rendering it ideal for wound dressing application.

中文翻译：

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利用水凝胶包埋龙眼籽提取物负载海藻酸盐/壳聚糖珠增强伤口敷料性能

水凝胶伤口敷料是用于促进愈合、吸收伤口渗出物、保持伤口周围局部湿润环境的重要医疗用品。在这项工作中，制备了嵌入明胶（Gel）和季铵化壳聚糖（QCS）水凝胶中的龙眼籽提取物（LSE）负载的藻酸盐（Alg）/壳聚糖（CS）珠，以维持LSE的释放并用作伤口敷料材料。研究了嵌入珠子和交联浓度对水凝胶性能的影响。 SEM 图像显示了水凝胶的互连多孔结构。通过增加交联浓度和嵌入珠子来改善水凝胶的机械性能、溶胀和重量损失。水凝胶系统成功改善了 LSE 的控制释放，表现出较低的细胞毒性，并支持细胞迁移，伤口闭合率达到 29%。因此，将负载 LSE 的 Alg/CS 珠嵌入水凝胶中，在增强水凝胶的特性和持续控制生物活性成分的释放方面表现出巨大的潜力，因此使其成为伤口敷料应用的理想选择。