Polypentamethylene guanidine sulfate (PPGS), a cationic antibacterial agent with low metal corrosivity, was synthesized by replacing chloride ions in polypentamethylene guanidine hydrochloride (PPMG) with sulfate ions using anion exchange resins. The results of corrosion experiments at high temperatures and in an aqueous solution suggested that PPGS exhibited better corrosion resistance than PPMG. The synthesized PPGS exhibited lower thermal stability and degradation occurred through the removal of sulfate groups. It showed strong intrinsic antimicrobial characteristics, which could change the morphological structure and rupture cell membranes. Furthermore, the minimal inhibitory concentrations of PPGS against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicans were approximately 8, 2, 16, and 12 ppm, respectively. Molecular simulations indicated that the positive charges accumulated on the PPGS surface can provide the driving force to attract bacteria with a negative charge on the cell membrane’s phospholipid layer.

中文翻译：

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离子交换法合成低金属腐蚀性、高抗菌性的有效胍盐低聚物

采用阴离子交换树脂用硫酸根离子取代聚五亚甲基胍盐酸盐（PPMG）中的氯离子，合成了低金属腐蚀性阳离子抗菌剂聚五亚甲基胍硫酸盐（PPGS）。高温和水溶液中的腐蚀实验结果表明，PPGS 比 PPMG 表现出更好的耐腐蚀性。合成的 PPGS 表现出较低的热稳定性，并且通过去除硫酸基团而发生降解。它表现出很强的内在抗菌特性，可以改变形态结构并破裂细胞膜。此外，PPGS对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和白色念珠菌的最低抑制浓度分别约为8、2、16和12 ppm。分子模拟表明，PPGS表面积累的正电荷可以提供驱动力来吸引细胞膜磷脂层上带负电荷的细菌。