A new strategy for the synthesis of 3‐substituted phthalides has been developed via a Lewis acid‐catalyzed intramolecular ring opening of aziridines with esters. Broad substrate scope, good yields and mild conditions made the cyclization reaction very suitable for the rapid construction of libraries of 3‐substituted phthalide compounds.

中文翻译：

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通过路易斯酸催化氮丙啶与酯的分子内开环构建3-取代的邻苯二甲酸酯

通过路易斯酸催化氮丙啶与酯的分子内开环，开发了一种合成 3-取代苯酞的新策略。广泛的底物范围、良好的产率和温和的条件使得环化反应非常适合快速构建3-取代苯并呋喃类化合物库。